Did you know that Sir James Black, the scientist who first developed the first clinically relevant beta-blocker propranolol, is also the discoverer of the first histamine H-2 antagonist Cimetidine?
Beta-blockers are used off-label for treating anxiety and migraine prophylaxis. Musicians have used beta-blockers to deal with stage fright.
Lipophilic beta-blockers seem to cross the blood-brain barrier and induce sleep disturbances like nightmares.
Since beta-blockers reduce heart rates, they are used as performance enhancers by many athletes in disciplines where it’s required a high degree of concentration and accuracy like shooting, archery, golf, and snooker. This is the reason why they are banned by the International Olympic Committee.
Beta-blockers for the same reason are used by surgeons during surgical operations.
The antidote for hypoglycemic coma induced by beta-blockers toxicity and overdose is Glucagon.
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