Some medications can affect taste giving abnormal, unpleasant, and an impaired sense of taste. This condition is called Dysgeusia, not to be confused with ageusia (complete loss of taste), hypogeusia (reduced sense of taste), and parageusia (altered sense of taste). When a medication is responsible for taste changes the condition is called drug-related or drug-induced taste disturbance and it is reversible which means it stops when the patient stops taking the medication. The risk of developing drug-related taste disturbance is higher in elderly patients in polytherapy, leading to diminished compliance.
Many drugs are responsible for taste disturbance and the main abnormalities can be discretionally divided into three categories: metallic taste, bitter taste, and generic unpleasant taste.
The medications that have been reported to induce taste disturbance are some antibiotics like macrolides, metronidazole, and tetracyclines, or antihypertensive medications like captopril (that can induce metallic taste); other medications like dorzolamide and some antiemetics can induce bitter taste disturbance; Quinolones, antifungals, antivirals, and many others can induce generic unpleasant taste disturbance.
References: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980431/
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