The first ACE inhibitor ever made is Captopril and it has been developed based on a molecule named teprotide, a nonapeptide found in the venom of the pit viper Bothrops jararaca.
ACE inhibitors are not as effective in the black population of patients and a calcium channel blocker should be considered as a first-line treatment or as an adjunct therapy.
ACE inhibitors such as Benazepril, enalapril, and ramipril are used in dogs and cats suffering from congestive heart failure.
Most of the ACE inhibitors are pro-drugs, which means that they require to be first metabolized to be active, except Lisinopril which does not require activation.
ACE inhibitors have shown positive outcomes in patients suffering from symptoms of schizophrenia-like polydipsia, a condition that increases fluids intake in absence of thirst stimuli.
https://commons.wikimedia.org/wiki/File:Bothrops_jararaca_02.jpg
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