Selective Serotonin Reuptake inhibitors (SSRIs) are used as first-line treatment for major depressive disorder, treatment-resistant depression disorder, post-traumatic stress disorder, generalized anxiety disorder, social anxiety disorder, panic disorder, bulimia nervosa, obsessive-compulsive disorder, and premenstrual dysphoric disorder. Off-label uses include premature ejaculation, binge eating disorder, fibromyalgia, and many others.
SSRIs work by selectively inhibiting the Serotonin presynaptic
transporter called SERT, raising the amount of the neurotransmitter Serotonin
in the synaptic cleft.
The SSRIs available on market are Fluoxetine (Prozac®),
Sertraline (Zoloft®), Paroxetine (Daparox®), Fluvoxamine (Luvox®), Citalopram
(Celexa®), Escitalopram (Cipralex®, Entact®) and Vilazodone (Viibryd®). They
are available in oral forms. None of them exist in injection form. All of them
can be taken with or without food except Vilazodone which should be taken with
food.
Side effects of SSRIs include weight gain, sexual
dysfunctions, headaches, prolonged QT interval, and increased risk of suicidal
thoughts in children and young adults.
Contraindications of SSRIs include concomitant use of MAOI,
linezolid, Setrons, and all those medications that can increase the risk of
serotonin syndrome. Among the SSRIs, Paroxetine should be avoided during
pregnancy.
Comments
Post a Comment