Even if bisoprolol is a selective B1 beta-blocker medication, which makes it less likely to give secondary effects from B2 inhibition, severe asthma, and severe COPD can be worsened by its effects. Also, marked sinus bradycardia, low blood pressure, and severe blood circulation in limbs like Raynaud’s phenomenon are all contraindications of bisoprolol.
The correct answer is D.
References
https://www.ncbi.nlm.nih.gov/books/NBK551623/
https://www.nhs.uk/medicines/bisoprolol/who-can-and-cannot-take-bisoprolol/
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