Many medications show efficacy in the prevention of migraines and some of them are used even off-label based on their positive outcomes. Beta-blockers without intrinsic sympathomimetic activity such as nadolol, bisoprolol, atenolol, metoprolol, timolol, and propranolol are used in the prevention of migraine. Several antiepileptic drugs (AEDs) are effective and are used for migraine prevention such as topiramate and valproate. Calcium Channel Blockers like Flunarizine and Verapamil are also used off-label for migraine prevention. Some antidepressants that show efficacy for the prevention of migraine are tricyclic antidepressant (TCA) amitriptyline and fluoxetine, a selective serotonin reuptake inhibitor (SSRI) fluoxetine.
The correct answer is C.
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