ACE inhibitors that belong to the dicarboxylate class are all pro-drugs, which means that they exist in an inactive form and they need to be activated, in this case by enzymes called carboxylesterase. The only ACE inhibitor of the dicarboxylate class that doesn’t need to be metabolized is Lisinopril (brand name Zestril among many others). The other ACE inhibitor that doesn’t need to be activated is Captopril.
The correct answer is D.
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