Phenylketonuria (PKU) is a condition where the blood levels of the amino acid phenylalanine are high and may cause serious side effects like permanent brain damage or intellectual disability. Phenylketonuria is caused by the deficiency of a gene that translates for a protein known as phenylalanine hydroxylase. The lack of this enzyme leads to increased levels of the amino acid phenylalanine. Some non-nutritive sweeteners like aspartame (a dipeptide containing phenylalanine) are likely to increase the risk of worsening the symptoms of phenylketonuria.
The correct answer is A.
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